![]() If needed, the protein sample could be optimized by conducting simple buffer screening. This feature is particularly valuable when screening a lot of samples, such as for sample optimization or screen a compound library for discovering novel ligands to bind to certain targets.įor protein structure determination, unlabeled protein could be used first by collecting simple 1D 1H NMR spectra to assess the spectral quality for suitability of NMR-based structural determination. The Bruker 800 and 500 MHz spectrometers are also equipped with automatic tuning and matching and automatic sample exchanger, thus allowing us to run samples continuously unattended day and night. ![]() The Bruker 800 MHz spectrometer is equipped with a sensitive TCI cryoprobe with pulse field gradients. The Carver College of Medicine NMR Core Facility has state of the art instrumentation including Bruker Avance II 800 MHz, Varian Unity Inova 600 MHz, and Bruker Avance II 500 MHz spectrometers. One of the primary experimental tools used in our laboratory is NMR spectroscopy. The molecular targets could be proteins, nucleic acids, oligosaccharides, drugs/metabolites, and/or their complexes. We are interested in molecular structure, function, dynamics, interaction, and recognition as well as metabolic profiling and drug discovery and development programs. ![]() ![]() Address: NMR Core Facility, B291 CBRB, 285 Newton Road ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |